Christopher R. Chappie: search on Z-Library

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1

Chemoproteomics Demonstrates Target Engagement and Exquisite Selectivity of the Clinical Phosphodiesterase 10A Inhibitor MP-10 in Its Native Environment

Schülke, Jan-Philip, McAllister, Laura A., Geoghegan, Kieran F., Parikh, Vinod, Chappie, Thomas A., Verhoest, Patrick R., Schmidt, Christopher J., Johnson, Douglas S., Brandon, Nicholas J.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 18.67 MB

english, 2014

2

Structures of the fungal dynamin-related protein Vps1 reveal a unique, open helical architecture

Varlakhanova, Natalia V., Alvarez, Frances J.D., Brady, Tyler M., Tornabene, Bryan A., Hosford, Christopher J., Chappie, Joshua S., Zhang, Peijun, Ford, Marijn G.J.

Journal:

The Journal of Cell Biology

Year:

2018

Language:

english

File:

PDF, 3.25 MB

english, 2018

3

Structural and Functional Characterization of the Dominant Negative PâLoop Lysine Mutation in the Dynamin Superfamily Protein Vps1

Tornabene, Bryan A., Varlakhanova, Natalia V., Hosford, Christopher J., Chappie, Joshua S., Ford, Marijn G. J.

Journal:

Protein Science

Year:

2020

Language:

english

File:

PDF, 2.88 MB

english, 2020

4

The Structure of a Eukaryotic Nicotinic Acid Phosphoribosyltransferase Reveals Structural Heterogeneity among Type II PRTases

Joshua S. Chappie, Jaume M. Cànaves, Gye Won Han, Christopher L. Rife, Qingping Xu, Raymond C. Stevens

Journal:

Year:

2005

Language:

english

File:

PDF, 894 KB

english, 2005

5

The role of diacylglycerol and activation of protein kinase C in α1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens

Richard P. Burt, Christopher R. Chappie, Ian Marshall

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.47 MB

english, 1996

6

Current Landscape of Phosphodiesterase 10A (PDE10A) Inhibition

Chappie, Thomas A., Helal, Christopher J., Hou, Xinjun

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 7.21 MB

english, 2012

7

Noradrenaline contractions of human prostate mediated by α1c-(α1c-) adrenoceptor subtype

Ian Marshall, Richard P. Burt, Christopher R. Chappie

Journal:

British Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.20 MB

english, 1995

8

Electrostatic Tuning of Ion Conductance in Potassium Channels

Nimigean, Crina M., Chappie, Joshua S., Miller, Christopher

Journal:

Year:

2003

Language:

english

File:

PDF, 225 KB

english, 2003

9

Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand

Zhang, Lei, Villalobos, Anabella, Beck, Elizabeth M., Bocan, Thomas, Chappie, Thomas A., Chen, Laigao, Grimwood, Sarah, Heck, Steven D., Helal, Christopher J., Hou, Xinjun, Humphrey, John M., Lu, Jiem

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 572 KB

english, 2013

10

Poster #S45 DEVELOPMENT OF NOVEL PET LIGANDS (PF-04831704 AND PF-06327104) FOR PDE10A

Ward, Karen M., Chen, Laigao, Zhang, Lei, Smith, Deborah, Chappie, Tom, Schmidt, Christopher, Grimwood, Sarah, O'Connor, Rebecca, Rizzo, Stacey, Schildknegt, Klaas

Journal:

Schizophrenia Research

Year:

2014

Language:

english

File:

PDF, 109 KB

english, 2014

11

Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia

Helal, Christopher J., Kang, Zhijun, Hou, Xinjun, Pandit, Jayvardhan, Chappie, Thomas A., Humphrey, John M., Marr, Eric S., Fennell, Kimberly F., Chenard, Lois K., Fox, Carol, Schmidt, Christopher J.,

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.96 MB

english, 2011

12

Discovery of a Series of 6,7-Dimethoxy-4-pyrrolidylquinazoline PDE10A Inhibitors †

Chappie, Thomas A., Humphrey, John M., Allen, Martin P., Estep, Kimberly G., Fox, Carol B., Lebel, Lorraine A., Liras, Spiros, Marr, Eric S., Menniti, Frank S., Pandit, Jayvardhan, Schmidt, Christophe

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 260 KB

english, 2007

13

Bladder, testicular neoplasm

Chappie, Christopher R.

Journal:

Current Opinion in Urology

Year:

1992

File:

PDF, 719 KB

1992

14

Female incontinence

Cutinha, Patrick E., Chappie, Christopher R.

Journal:

Current Opinion in Urology

Year:

1996

File:

PDF, 734 KB

1996

15

Bimonthly Update in Urology

Chappie, Christopher R.

Journal:

Current Opinion in Urology

Year:

1992

File:

PDF, 28 KB

1992

16

Bimonthly Update in Urology

Chappie, Christopher R.

Journal:

Current Opinion in Urology

Year:

1992

File:

PDF, 4.46 MB

1992

17

Correlation of symptomatology, urodynamics, morphology and size of the prostate in benign prostatic hyperplasia

Chappie, Christopher R.

Journal:

Current Opinion in Urology

Year:

1993

File:

PDF, 410 KB

1993

18

Surgery, reconstructive surgery

Chappie, Christopher R.

Journal:

Current Opinion in Urology

Year:

1991

File:

PDF, 385 KB

1991

19

Prostate

Chappie, Christopher R.

Journal:

Current Opinion in Urology

Year:

1991

File:

PDF, 560 KB

1991

20

Prostate

Chappie, Christopher R.

Journal:

Current Opinion in Urology

Year:

1992

File:

PDF, 470 KB

1992

21

Surgery, reconstructive surgery

Chappie, Christopher R.

Journal:

Current Opinion in Urology

Year:

1991

File:

PDF, 456 KB

1991

22

Content

Chappie, Christopher R

Journal:

Current Opinion in Urology

Year:

1997

File:

PDF, 23 KB

1997

23

Alpha-blocker update ??? prostate-selective blockade

Chappie, Christopher R.

Journal:

Current Opinion in Urology

Year:

1997

File:

PDF, 705 KB

1997

24

Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

Helal, Christopher J., Arnold, Eric P, Boyden, Tracey L, Chang, Cheng, Chappie, Thomas A., Fennell, Kimberly F., Forman, Michael D, Hajós, Mihaly, Harms, John F., Hoffmann, William E., Humphrey, John

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.51 MB

english, 2017

25

Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate

Helal, Christopher J., Arnold, Eric P, Boyden, Tracey L, Chang, Cheng, Chappie, Thomas A., Fisher, Ethan, Hajós, Mihaly, Harms, John F., Hoffmann, William E., Humphrey, John M., Pandit, Jayvardhan, Ka

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 967 KB

english, 2018

26

Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

Helal, Christopher J., Arnold, Eric P., Boyden, Tracey L., Chang, Cheng, Chappie, Thomas A., Fennell, Kimberly F., Forman, Michael D., Hajos, Mihaly, Harms, John F., Hoffman, William E., Humphrey, Joh

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 187 KB

english, 2018

27

Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1

Humphrey, John M., Movsesian, Matthew, am Ende, Christopher W., Becker, Stacey L, Chappie, Thomas A., Jenkinson, Stephen, Liras, Jennifer L, Liras, Spiros, Orozco, Christine C, Pandit, Jayvardhan, Vaj

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 548 KB

english, 2018

28

The crystal structure of the Helicobacter pylori LlaJI.R1 N-terminal domain provides a model for site-specific DNA binding

Hosford, Christopher J, Chappie, Joshua S

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 8.92 MB

english, 2018

29

Surgery for Stroke

Croft, Rodney J, Harrison, Michael J G, Marston, Adrian, Chappie, Christopher, Thakkar, Rajesh

Journal:

Journal of the Royal Society of Medicine

Year:

1981

Language:

english

File:

PDF, 543 KB

english, 1981

30

Structural characterization of Class 2 OLD family nucleases supports a two-metal catalysis mechanism for cleavage

Schiltz, Carl J, Lee, April, Partlow, Edward A, Hosford, Christopher J, Chappie, Joshua S

Journal:

Nucleic Acids Research

Year:

2019

Language:

english

File:

PDF, 9.77 MB

english, 2019

31

The structure of the Thermococcus gammatolerans McrB N-terminal domain reveals a new mode of substrate recognition and specificity among McrB homologs

Hosford, Christopher J., Bui, Anthony Q., Chappie, Joshua S.

Journal:

Journal of Biological Chemistry

Year:

2020

Language:

english

File:

PDF, 4.64 MB

english, 2020

32

The N-terminal domain of Staphylothermus marinus McrB shares structural homology with PUA-like RNA binding proteins

Hosford, Christopher J., Adams, Myfanwy C., Niu, Yiming, Chappie, Joshua S.

Journal:

Journal of Structural Biology

Year:

2020

File:

PDF, 597 KB

2020

33

Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes

Niu, Yiming, Suzuki, Hiroshi, Hosford, Christopher J., Walz, Thomas, Chappie, Joshua S.

Journal:

Nature Communications

Year:

2020

File:

PDF, 3.11 MB

2020

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